Guide

Medication for anxiety

General information rather than medical advice. Two things are worth knowing before the conversation: SSRIs often make anxiety worse for the first fortnight, and benzodiazepines interact badly with the treatment that works.

Reviewed by Albert Wong, PhDClinical psychologistLast reviewed September 2026About this site

Medication for anxiety works, and the decision belongs with a prescriber who knows your history. What follows is the context that makes that conversation more useful.

SSRIs and SNRIs

First-line, with good evidence across generalized anxiety, panic, and social anxiety. Sertraline, escitalopram, paroxetine, venlafaxine and duloxetine are all commonly used.

Two things people aren’t told often enough.

They usually make anxiety worse first. The first one to two weeks frequently bring increased jitteriness, restlessness and sometimes nausea. This is expected, it passes, and it’s the single commonest reason people stop before the medication has had a chance. Starting at a low dose and increasing slowly reduces it considerably — worth asking for explicitly if you’ve panic.

They take four to six weeks. Sometimes longer for full effect. Judging at week two is judging the side effects.

Coming off should be done slowly and with a plan. Discontinuation symptoms are real, and paroxetine and venlafaxine in particular need a careful taper.

Benzodiazepines

They work fast and well, which is exactly the problem.

Tolerance develops, dependence develops, and withdrawal can be protracted and genuinely difficult. Guidelines uniformly recommend short-term use only, and long-term prescribing for anxiety has fallen out of favour for good reasons.

There’s a second, subtler issue that matters for anyone doing therapy. Taking one before a feared situation is a safety behaviour: the situation gets survived, and the credit goes to the tablet, so the learning doesn’t happen. There’s research suggesting benzodiazepine use during exposure treatment worsens outcomes for exactly this reason.

If you carry one and never take it, that unopened packet is doing the same job, and clinicians will usually work toward leaving it at home.

Beta blockers

Propranolol reduces the physical symptoms — trembling, palpitations, shaky voice — without touching the fear itself. Useful for discrete performance situations. Used every time, the same safety-behaviour problem applies.

How it pairs with therapy

Combined treatment is generally at least as good as either alone in the short term. The interesting finding is what happens afterwards: CBT’s gains hold better after treatment ends, while relapse on stopping medication alone is common.

The practical implication isn’t that medication is inferior. It’s that medication plus therapy, with the therapy done properly, gives you something that survives the medication stopping.

Questions worth asking

What are the first two weeks likely to feel like, and can we start lower? How long before we judge it? What is the plan if it doesn’t work? And how long would you expect me to stay on it, and how would we stop?

Keep reading

47 guides on anxiety and what treats it, free and without an account. There is a directory of therapists here too — it is new, and growing.

General information, not clinical advice; the people described are composites, not real clients. New or sudden physical symptoms deserve a medical opinion before they are called anxiety. Listings on this site are maintained by independent practices. If you are in immediate danger, call 911; the 988 Suicide & Crisis Lifeline is available by call or text any time.